Hypophysitis is a rare condition which involves the extreme or chronic inflammation of the pituitary gland or pituitary stalk. The most common form is lymphocytic Hypophysitis which is assumed to be an autoimmune disorder. It was believed to affect women during or after pregnancy, it is now acknowledged as a disease affecting both males and females and over a large age range. In addition, a new form has currently been defined in patients receiving immunotherapy remedy for cancer – basically those with metastatic cancer being dealt with anti-CTLA4 and anti-PDi treatment.