Psychoneuroendocrinology is the clinical approach of hormone fluctuations and their courting to human behavior. It can be regarded from the perspective of psychiatry, wherein certain mood disorders, that are related to neuroendocrine or hormonal adjustments affecting the brain. It may additionally be regarded from the angle of endocrinology, where certain endocrine disorders may be related to poor health consequences and psychiatric illness. Brain dysfunctions associated with the hypothalamus-pituitary-adrenal axis HPA axis can affect the endocrine system, which in flip can bring about physiological and psychological symptoms. This complex combo of psychiatry, psychology, neurology, biochemistry, and endocrinology is needed to comprehensively recognize and treat signs and symptoms related to the brain, endocrine system (hormones), and mental health.