Hereditary Paragangliomas

Hereditary paraganglioma-pheochromocytoma is an inherited situation characterized by the growth of noncancerous (benign) tumors in structures referred to as paraganglia. Paraganglia are groups of cells which can be found close to nerve mobile bunches known as ganglia. A tumor concerning the paraganglia is referred to as a paraganglioma. A type of paraganglioma called a pheochromocytoma develops inside the adrenal glands, which are placed on top of every kidney and produce hormones in response to stress. Other styles of paraganglioma are typically discovered in the head, neck, or trunk. People with hereditary paraganglioma-pheochromocytoma broaden one or more paragangliomas, which may encompass pheochromocytomas.

Pheochromocytomas and some different paragangliomas are associated with ganglia of the sympathetic nervous machine. The sympathetic nervous device controls the "fight-or-flight" reaction, a chain of changes inside the body due to hormones released in response to stress. Sympathetic paragangliomas located out of doors the adrenal glands, normally inside the abdomen, are referred to as extra-adrenal paragangliomas. Most sympathetic paragangliomas, which includes pheochromocytomas, produce hormones called catecholamines, together with epinephrine (adrenaline) or norepinephrine. These extra catecholamines can cause symptoms and symptoms consisting of excessive blood pressure (hypertension), episodes of rapid heartbeat (palpitations), headaches, or sweating.