Lipid Metabolism and Diabetes

Diabetes mellitus is the most frequent endogenous motive of fats metabolism-disorder. In diabetics, the threat for arteriosclerosis is significantly high and the clinical significance of hyperlipidaemia should be expected extra serious as in non-diabetics. The principal abnormality of fat metabolism in diabetes is hypertriglyceridemia due to a boom of triglyceride-carrying lipoproteins, the chylomicrons and the very-low-density lipoproteins. In type I-diabetics the decisive pathogenic factor for hypertriglyceridemia is the impaired degradation of VLDL and the reduced chylomicron-clearance, because of decreased interest of the lipoprotein lipase. In ketoacidosis, there may be additional growth in hepatic VLDL-triglyceride-production because of extended lipolysis with increased free-fatty-acid flux. Total LDL cholesterol in-kind I-diabetics is handiest drastically expanded whilst metabolic control is poor, low-density lipoprotein (LDL-)-cholesterol-levels can be extended and high-density lipoprotein (HDL-)cholesterol reduced independence on the metabolic manipulate. In type II-diabetics the decisive pathogenic factor for hypertriglyceridemia is improved VLDL-triglyceride-synthesis in the liver especially because of augmented free-fatty-acid flux. Additionally, the hobby of the lipoprotein lipase may be reduced. Usually, in non-insulin-established diabetics, LDL- cholesterol-levels may be seen expanded and HDL-cholesterol-concentration reduced in correlation with the metabolic manage. Primary hypolipoproteinaemia appears regularly in diabetics, but this may be explained by using the association with weight problems in type II-diabetics.

  • Epidemiology
  • Diabetic dyslipidaemia
  • Pathophysiology
  • Residual cardiovascular risk